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KMID : 1140120090140010054
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Cancer Prevention Research
2009 Volume.14 No. 1 p.54 ~ p.59
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Inhibitory Properties of Tumor Growth by Quercetin in Xenograft Models
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Lee Yoon-Kyoung
Lee Won-Sup
Shin Jang-In
Lee Hee-Gu
Hwang Jin-Taek
Park Ock-Jin
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Abstract
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Quercetin is a flavonoid found in many fruits, vegetables and tea and exerts anti-tumor activity in several tumor models. In this study, we have examined the tumor growth inhibitory effect of quercetin in MCF-7 xenograft models using female and male mice and observed alteration of signaling molecules involved in cell survival and apoptosis. Our results showed that administration of 50μg/g quercetin daily significantly inhibited tumor growth in both female and male MCF-7 xenograft models. It has shown that quercetin increases the activation of AMP-activated protein kinase (AMPK) along with tumor regression. AMPK is a major signaling molecule for the regulation of energy metabolism. Recent studies indicated that AMPK acts as a master controller in cancer cells through regulating several survival-related pathways. Phosphorylated Akt and Cycloxygenase-2 (COX-2) levels were found to be related to anti-tumor activities of quercetin. The results suggested that quercetin has a potential anti-tumor activity against breast cancer and it may be related to suppression of oncogenic molecules such as Akt and COX-2, and activation of pro-apoptotic molecules such as AMPK.
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KEYWORD
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Quercetin, AMP-activated protein kinase, Akt, Cyclooxygenase-2, MCF-7 xenograft
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